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OmniGuard® Advance Mattress Protector

Regular price $125.00
Regular price Sale price $125.00
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Our award-winning OmniGuard® Advance mattress protector covers the top and sides of your mattress, creating a 5-sided barrier against moisture, allergens, dust mites, mold, mildew, and stains.

OmniGuard® Advance is the unique base fabric used throughout our entire collection of premium mattress and pillow protectors. Designed to deliver the highest standards of cleaner sleep and whisper-quiet protection, it’s no wonder why our OmniGuard® collection has earned the title of the official protectors of both the Women’s Choice Award and the National Sleep Foundation.

  • Premium Quality Products

  • Dedicated Customer Support

  • Best Price guaranteed


  • Designed to fit like a fitted sheet over the following mattress depths:
    • Twin / Twin XL / Full / Full XL: 15" deep 
    • Queen / Split Queen: 17” deep
    • King / Cal King: 17.5” deep
  • Our lightweight and flexible OmniGuard® Advance protectors are recommended for use on both adjustable and standard bases and provide ideal protection for any mattress material.
  • 10 year warranty

    STANDARD 100 by OEKO-TEX® internationally renowned independent textile testing ensures that our products are safe from harmful substances.
    (21.HUS.54899 I HOHENSTEIN HTTI)


Easy laundry tips for our protectors:

Our 5-sided OmniGuard Advance® mattress protector fits like a fitted sheet over your mattress, making it easy to remove and wash. On laundry day, leave your total encasement mattress protector zipped around your mattress for 360° protection while you wash and dry your OmniGuard mattress protector on hot for optimal sanitization.

The antimicrobial properties on our treated products remain active for over 50 washings and never impact the comfort or softness of our fabrics.

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Protection + OmniGuard Advance®

Wake Rested Thanks to Cleaner Sleep

Like it or not, the warm, moist environment of your sleep surface can create the ideal incubator for allergens and bacteria to multiply within your bedding. Whether you suffer from allergies, allergen-induced asthma, or are simply waking up stuffy with dark eye circles, you need relief from allergen buildup in your sleep environment. Our antimicrobial silver product protection helps keep your bedding fresher longer by inhibiting bacteria, mold, and mildew that cause deterioration, stains and odors on this product.

Designed for Cleaner Comfort

Layer our ultra-thin OmniGuard® Advance mattress protector under any of our premium sheets, pillows, or blankets to start creating a cleaner, more comfortable sleep space. Our breathable, 4-way circular stretch knit OmniGuard® Advance fabric is whisper-quiet, providing a protective barrier that you won’t even know is there. Cleaner sleep starts here and is enhanced by our double-bound MiteTight® seams for extra protection against allergens and irritants.

Clinically Proven Protection

We know how important it is that our products deliver the moisture and allergen protection you need for cleaner sleep. That’s why we seek out hygiene experts like Dr. Philip M. Tierno, Dir. of Clinical Microbiology & Immunology at NYU Langone Medical Center, to help test our protector fabric. It’s one more way we ensure that our products truly help you create a cleaner, more hygienic sleep sanctuary for you and those you love. These benefits and more are built into every premium protector we design.

Frequently Asked Questions

Does this product qualify for bundle savings?
Yes—mix and match our premium sleep essentials to enjoy up to 40% off site wide!
Can I order fabric swatches?
Coming soon! Please check back.
What is the difference between a mattress protector and a mattress pad?
While mattress pads are designed to provide an extra layer of comfort for the top of your mattress, they are not designed to provide protection. This mattress protector is specifically designed to provide an ultra-thin physical barrier that will not changing the comfort of your mattresses.
How do I care for/wash this protector?
Our OmniGuard® Advance fabric should be washed and dried on hot to provide the cleanest, most hygienic sleep surface.
What certifications does this protector have?
Vartest® Certified Our OmniGuard® Advance fabric has passed the highest barrier performance test established by the Centers for Disease Control and is certified to block viruses 32 nanometers in diameter. Covid-19 is approximately 125 nanometers in diameter. Women's Choice Award Our entire collection of premium mattress and pillow protectors are the official protectors of the Women's Choice Award. This award certifies that 9 out of 10 women surveyed would recommend our products to friends and family. Learn more at National Sleep Foundation Finally, our protectors are the official mattress and pillow protectors of the National Sleep Foundation.
Is this product STANDARD 100 by OEKO-TEX® Certified?
Yes. All of our products are OEKO-TEX® STANDARD 100 certified, one of the world's best-known labels for textiles tested for harmful substances. It stands for customer confidence and high product safety. Find out more at STANDARD 100 by OEKO-TEX® (21.HUS.54899 I HOHENSTEIN HTTI)

Customer Reviews

Erin Davidson

We are so happy with the customer service and quality of selection here! Teresa was very welcoming and answered all of our MANY questions. She gave us genuine advice and spent quality time helping us make the best decision. We are sleeping better than ever. Delivery was easy and prompt

Ginger Vieira

I'll never buy a bed anywhere else! Affordable, friendly, and SO easy to work with! I've purchased maybe 5 mattresses now from these folks. The owner is often standing right there at the desk. They delivery, set-up your frame, etc. So wonderful and personable and real. No nonsense. How a VT-owned business should be.

Carla Cyr

The mattress set I bought has been amazing , love it so much, went back and bought a bureau ThAt is Amish made it is so beautiful. I am buying a matching bed frame now. I also bought a mattress cover , it was easy to but on and works so well!! Thank you Sean and Theresa!!!

James D.

This store is run by a young husband and wife with a 3 1/2 yr old kid who plays quietly behind the counter. When I entered, they greeted me but didn’t bum-rush me, which would have been annoying. Once I approached them, they were helpful, knowledgeable, and was able to get me exactly what I wanted and then through in a small discount.

Chris Leach

Just got our bed from Vermont Mattress Depot yesterday. I had the mattress delivered the very next day! They were courteous from beginning to end. The delivery guys were super friendly and careful. We have a tiny upstairs apartment and they were able to navigate our narrow hallways with ease! Speaking from experience, in all my 36 revolutions around the earth, this has been by far the best night sleep.

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